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Space agencies should first undertake Human mission to Mars's little moons before attempting Mars's surface
Human mission to Phobos or Deimos would require 1000 days in microgravity. Currently the longest ever time spent in space is 438 days.
Doubling the number of days for humans spend in microgravity might enlarge health risks but is not impossible with current technology.
A Human mission to the surface of Mars would require practically the same time in microgravity or even more then a mission to it's moons because of the complex manoeuvres and preparation required to landing and relaunching a spacecraft on a high gravity object as Mars.
Most time spent by humans on space was in the ISS and Mir stations, both of which are inside the magnetosphere. Going to Mars poses completely different risks.